Page 12 · Lehigh University Facullty News Steve Regen Professor Regen has been traveling both nationally and internationally within the last year to share his research into molecular assembly, materials, and nanoscience. His timely pre-COVID-19 research regarding cell permeability provided outstanding insights for conference attendees. He gave invited talks as follows: Department of Energy Workshop, Washington, D.C., "Hyperthin Membranes for Gas Separations", September 2019. University of Lisbon, Portugal "The Driving Force for Lipid Raft Formation", October 2019. The Gordon Research Conference, Galveston, TX "Gas Transport Across Hyperthin Polyelectrolyte Multilayers", January 2020 In addition, Regen and his research colleagues and graduate students published the following papers: Pramanik, N. B..; Regen, S. L. “Hyperthin Membranes for Gas Separations Via Layer-By-Layer Assembly” Chem. Rec. 2019, 19, 1-12. Pramanik, N. B.; Regen, S. L. “Clicking the Surface of Poly[1-(Trimethylsilyl)propyne](PTMSP) via a Thiol-ene Reaction: Unexpected CO2/N2 permeability” Langmuir 2020, 36, 1768-1772. Damien Thévenin During the past year, the Thévenin Lab has continued to develop novel strategies to selectively target tumors for therapeutic purposes. Particularly, the group synthesized a set of peptides capable of re-engaging the immune response to attack cancer cells specifically. In addition, our effort to understand the role of an essential but not fully understood family of human proteins (the Receptor Protein-Tyrosine Phosphatases) and to develop a new class of agents against these proteins for therapeutic purposes has recently been recognized by the National Institutes of Health with a $1.6 million R01 award. Finally, our group, in collaboration with Dr. Aurelia HonerkmapSmith (Department of Physics at Lehigh), has been awarded a $300,000 New Initiative grant from the Charles E. Kaufman Foundation aimed at quantitatively define and predict how cells sense, interpret, and respond to shear flow, an essential phenomemon underlying multiple important biological processes, such as cardiovascular health and embryonic development. The group also published the following papers: Wehr J.; Sikorski E.L.; Bloch E.; Feigman M.S.; Ferraro N.J.; Baybutt T.R.; Snook A.E.; Pires M.M. and Thévenin, D. "pHDependent Grafting of Cancer Cells with Antigenic Epitopes Promotes Selective Antibody-Mediated Cytotoxicity" J Med Chem. 2020, 63, 7, 3713–3722. Bloch, E.; Sikorski, E.L.; Pontoriero, D.; Day, E.K.; Berger, B.W.; Lazzara, M.J. and Thévenin, D. "Disrupting the Transmembrane Domain-Mediated Oligomerization of Protein Tyrosine Phosphatase Receptor J Inhibits EGFR-Driven Cancer Cell Phenotypes" J Biol Chem. 2019, 294, 49, 18796–18806. Vasquez-Montes, V.; Gerhart, J.; Thévenin, D. and Ladokhin, A.S. "Divalent Cations and Lipid Composition Modulate Membrane Insertion and Cancer-Targeting Action of pHLIP" Journal of Molecular Biology 2019, 431, 24, 5004–5018. During the 2019-2020 academic year, Dr. Landskron and his colleagues published the following papers: Zhu, S.; Li, J.; Toth, A.; Landskron, K. “Relationships between the Elemental Composition of Electrolytes and the Supercapacitive Swing Adsorption of CO2” ACS Applied Energy Materials 2019, 2, 7449-7456 Kai Landskron Stepniowski, W. J.; Paliwoda, D.; Abrahami, S. T.; Michalska-Domanska, M.; Landskron, K.; Buijnsters, J. G.; Mol, J. M. C.; Terryn, H.; Misiolek, W. Z. “Nanorods Grown by Copper Anodizing in Sodium Carbonate” Journal of Electroanalytical Chemistry 2020, 857, 113628
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