Page 7 • Lehigh University Since the last newsletter, the Vicic Group received an NSF grant to develop nickel-catalyzed methods to prepare high-value organofluorine molecules. David gave invited lectures at University of Cincinnati, University of Shanghai (virtual), Mississippi State University, the 2022 ACS Northeast Regional Meeting in Rochester NY, the 20th European Symposium on Fluorine Chemistry in Berlin (where David also served as a poster judge), and the 26th Annual Green Chemistry & Engineering Conference in Reston VA. David also gave a poster presentation at the 2022 Organometallic Chemistry Gordon Research Conference at Salve Regina University. David Vicic has served as the Chair of the ACS Winter Fluorine Conference (WFC) that was held in Clearwater, FL in January 2023. The WFC is the flagship meeting of the ACS Division of Fluorine Chemistry and attracts top academic and industrial scientists from around the world. The published scientific contributions from the group include: “Synthesis, Characterization, and Solution Behavior of Solvated Perfluoroethyl and n-Perfluoropropyl Cobalt (III) Complexes” Xue, T.; Shreiber, S. T.; Cramer, R. E.; Vicic, D. A. J. Fluorine Chem. 2022, 261-262, 110030. “Transformation of brucine into trifluoromethyl neobrucine using the homoleptic nickel catalyst [Ni(CF 3 ) 4 ] 2 - ” Shreiber, S. T.; Puchall, G. I.; Vicic, D. A. Tetrahedron Lett. 2022, 97, 153795. “Synthesis, Structure, and Electrochemical Properties of [LNi(R f )(C 4 F 8 )] – and [LNi(R f ) 3 ] – Complexes” Tumors” and (2) "Off-the-shelf CAR-T Therapy via Tumor-Selective Immuno-engagers”. In addition, the lab received as a collaborator with the Honerkamp-Smith Lab (Department of Physics) an NIH R01 award aimed at elucidating how proteins at the surface of cell membranes respond to fluid flow and how they trigger intracellular signaling in endothelial cells. The lab also welcomed two talented new graduate students: Leah Knepper and Walter Espinoza Paz. Prof. Thévenin gave invited talks at the EMBO Workshop (Reversible phosphorylation, signal integration, and drug discovery) and Biophysical Society Meeting (Molecular Biophysics of Membranes) on the group’s work on receptor protein tyrosine phosphatases. Prof. Thévenin is also now an Editor for the Journal of Membrane Biology, and is editing the new edition of the book on Protein Tyrosine Phosphatases, to be published in the well -established lab protocol series Methods in Molecular Biology. Finally, the group published the following research articles: Vasquez‐Montes, V.; Tyagi, V.; Sikorski, E.; Kyrychenko, A.; Freites, J. A.; Thévenin, D.; Tobias, D. J.; Ladokhin, A. S. Ca2+ ‐dependent Interactions between Lipids and the Tumor‐targeting Peptide PHLIP. Protein Science 2022, 31 (9). https://doi.org/10.1002/pro.4385. Vasquez-Montes, V.; Goldberg, A. F. X.; Thévenin, D.; Ladokhin, A. S. Ca2+ and Mg2+ Influence the Thermodynamics of Peptide-Membrane Interactions. Journal of Molecular Biology 2022, 167826. https:// doi.org/10.1016/j.jmb.2022.167826. Sikorski, E. L.; Wehr, J.; Ferraro, N. J.; Rizzo, S. M.; Pires, M. M.; Thévenin, D. Selective Display of a Chemoattractant Agonist on Cancer Cells Activates the Formyl Peptide Receptor 1 on Immune Cells**. ChemBioChem 2022, 23 (8). https://doi.org/10.1002/cbic.202100521.
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