CONGRATULATIONS GRANT AWARD RECIPIENTS FISHER LAB >> FISHER LAB >> FISHER LAB > HER LA A recent recipient of a $250K National Science Foundation grant award, Professor Oriana Fisher and her students will study the behavior of copper ions in bacteria using a wide range of chemical and biochemical techniques. The research will provide a detailed understanding of how bacteria process copper and this will help lead to a better understanding of the chemistry of antibiotic resistance. Dr. Fisher’s plan to pilot a summer research program that will recruit students from groups underrepresented in science will broaden participation in chemistry at Lehigh and will provide long-termmentoring of a cohort of underrepresented minority students as they navigate the transition from undergraduate to graduate school. The Glover Lab is very elated about receiving a $475K National Institutes of Health grant award to continue their research on the caveolin protein. The caveolin protein is critical for cellular homeostasis--and aberrant caveolin behavior has been implicated in a number of human maladies including cancers and heart disease. Specifically in this award, they aim to take a multi-faceted approach utilizing NMR, molecular dynamics simulations, and fluorescence spectroscopy to determine the three-dimensional conformation of caveolin in a bilayer. In addition, unique experiments are planned to explore the oligomeric state of caveolin using the lipid cubic phase. The Glover Lab is also enthused to be collaborating with Drs. Wonpil Im of Lehigh University and Kyle Root of Lockhaven University on this important, far-reaching, and exciting project! RECEIVES NIH AWARD TO FURTHER CAVEOLIN PROTEIN RESEARCH extracellularly--and investigating the structural and biophysical basis for transcriptional control of the ycn operon, which may hold a key to understanding bacterial copper acquisition and regulation. While copper export proteins are highly conserved throughout evolution, copper importers in bacteria appear to be completely distinct from their eukaryotic counterparts. Previous studies have focused on this problem primarily from a biological perspective; research under this award will provide new insight into a molecular level understanding of proteins that govern these processes. This award is funded under the American Rescue Plan Act of 2021 and reflects NSF's statutory mission. The Fisher Lab project has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria. FISHER LAB'S NSF AWARD FUNDS COPPER IONS IN BACTERIA RESEARCH--AND OFFERS SCIENTIFIC RESEARCH OPPORTUNITIES FOR UNDERREPRESENTEDMINORITY STUDENTS Professor Fisher will biophysically and structurally elucidate proteins that orchestrate copper acquisition in Bacillus subtilis, with the aims of elucidating how Cu is recognized and chaperoned Department of Chemistry · Page 5
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